{"id":13008,"date":"2025-07-23T09:37:40","date_gmt":"2025-07-23T01:37:40","guid":{"rendered":"https:\/\/www.shorro.cn\/index.php\/archives\/13008"},"modified":"2025-07-23T09:37:40","modified_gmt":"2025-07-23T01:37:40","slug":"dbu%e4%ba%8c%e6%b0%ae%e6%9d%82%e4%ba%8c%e7%8e%af%e4%bd%9c%e4%b8%ba%e5%a4%9a%e5%8a%9f%e8%83%bd%e9%9d%9e%e8%83%ba%e7%b1%bb%e5%82%ac%e5%8c%96%e5%89%82%e5%9c%a8%e6%9c%89%e6%9c%ba%e5%90%88%e6%88%90","status":"publish","type":"post","link":"https:\/\/www.shorro.cn\/index.php\/archives\/13008","title":{"rendered":"DBU\u4e8c\u6c2e\u6742\u4e8c\u73af\u4f5c\u4e3a\u591a\u529f\u80fd\u975e\u80fa\u7c7b\u50ac\u5316\u5242\u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

\u5728\u6709\u673a\u5408\u6210\u7684\u6c5f\u6e56\u91cc\uff0c\u50ac\u5316\u5242\u662f\u90a3\u628a\u6253\u5f00\u795e\u79d8\u4e4b\u95e8\u7684\u94a5\u5319\u3002\u6709\u4eba\u504f\u7231\u8fc7\u6e21\u91d1\u5c5e\uff0c\u50cf\u91d1\u5eb8\u7b14\u4e0b\u7684\u201c\u5251\u795e\u201d\u822c\u950b\u8292\u6bd5\u9732\uff1b\u6709\u4eba\u949f\u60c5\u4e8e\u9176\u50ac\u5316\uff0c\u5b9b\u5982\u201c\u533b\u4ed9\u201d\u822c\u6e29\u6da6\u7ec6\u817b\u3002\u800c\u4eca\u5929\u6211\u4eec\u8981\u804a\u7684\u8fd9\u4f4d\u201c\u4fa0\u5ba2\u201d\uff0c\u65e2\u4e0d\u8d70\u91d1\u5c5e\u8def\u7ebf\uff0c\u4e5f\u4e0d\u9760\u751f\u7269\u52a0\u6301\uff0c\u5374\u51ed\u501f\u4e00\u8eab\u8f7b\u76c8\u8eab\u6cd5\u548c\u767e\u53d8\u62db\u5f0f\uff0c\u5728\u4f17\u591a\u53cd\u5e94\u4e2d\u6e38\u5203\u6709\u4f59\u2014\u2014\u5b83\u5c31\u662f\u4e8c\u6c2e\u6742\u4e8c\u73af\u8f9b\u70f7\uff0c\u7b80\u79f0DBU\u3002<\/p>\n

\u522b\u770b\u8fd9\u540d\u5b57\u957f\u5f97\u50cf\u6781\u4e86\u5316\u5b66\u8bfe\u672c\u91cc\u7528\u6765\u5413\u9000\u6587\u79d1\u751f\u7684\u672f\u8bed\uff0c\u5176\u5b9e\u5b83\u5728\u5708\u5185\u65e9\u5df2\u58f0\u540d\u8fdc\u64ad\u3002DBU\uff0c\u5168\u79f01,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef\uff081,8-Diazabicyclo[5.4.0]undec-7-ene\uff09\uff0c\u662f\u4e00\u79cd\u5f3a\u78b1\u6027\u3001\u975e\u4eb2\u6838\u6027\u7684\u6709\u673a\u78b1\u50ac\u5316\u5242\u3002\u5b83\u7684\u7ed3\u6784\u50cf\u4e00\u5ea7\u5fae\u578b\u7684\u7acb\u4f53\u8ff7\u5bab\uff0c\u4e24\u4e2a\u6c2e\u539f\u5b50\u5206\u522b\u4f4d\u4e8e\u6865\u5934\u4f4d\u7f6e\uff0c\u4e00\u4e2a\u5e26\u5b64\u5bf9\u7535\u5b50\uff0c\u53e6\u4e00\u4e2a\u5219\u53c2\u4e0e\u5f62\u6210\u5171\u8f6d\u4f53\u7cfb\uff0c\u8fd9\u79cd\u7cbe\u5de7\u5e03\u5c40\u8ba9\u5b83\u5728\u9178\u78b1\u53cd\u5e94\u4e2d\u5982\u9c7c\u5f97\u6c34\u3002<\/p>\n

\u4e00\u3001\u201c\u6587\u80fd\u63d0\u7b14\u5b89\u5929\u4e0b\u201d\uff1aDBU\u7684\u7269\u7406\u4e0e\u5316\u5b66\u53c2\u6570<\/h3>\n

\u8981\u8bf4\u8ba4\u8bc6\u4e00\u4e2a\u4eba\uff0c\u5148\u5f97\u77e5\u9053\u4ed6\u7684\u8eab\u9ad8\u4f53\u91cd\u3001\u6027\u683c\u813e\u6c14\u3002DBU\u4e5f\u4e00\u6837\uff0c\u54b1\u4eec\u5148\u6765\u6252\u4e00\u6252\u5b83\u7684\u57fa\u672c\u8d44\u6599\u3002<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u53c2\u6570\u9879<\/th>\n\u6570\u503c\/\u63cf\u8ff0<\/th>\n<\/tr>\n<\/thead>\n
\u5206\u5b50\u5f0f<\/td>\nC\u2089H\u2081\u2086N\u2082<\/td>\n<\/tr>\n
\u5206\u5b50\u91cf<\/td>\n152.24 g\/mol<\/td>\n<\/tr>\n
\u5916\u89c2<\/td>\n\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u6db2\u4f53<\/td>\n<\/tr>\n
\u6cb8\u70b9<\/td>\n\u7ea6275\u00b0C\uff08\u5206\u89e3\uff09<\/td>\n<\/tr>\n
\u7194\u70b9<\/td>\n\u7ea634\u201336\u00b0C<\/td>\n<\/tr>\n
\u5bc6\u5ea6<\/td>\n0.98 g\/cm\u00b3\uff0825\u00b0C\uff09<\/td>\n<\/tr>\n
pKa\uff08\u5171\u8f6d\u9178\uff09<\/td>\n\u7ea611.5\u201312\uff08\u5728\u6c34\u4e2d\uff09<\/td>\n<\/tr>\n
\u6eb6\u89e3\u6027<\/td>\n\u6613\u6eb6\u4e8e\u6c34\u3001\u3001\u4e59\u8148\u3001\u4e8c\u6c2f\u7532\u70f7\u7b49\u5e38\u89c1\u6eb6\u5242<\/td>\n<\/tr>\n
\u78b1\u6027\u5f3a\u5ea6<\/td>\n\u5f3a\u4e8e\u4e09\u4e59\u80fa\uff0c\u5f31\u4e8e\u6c22\u5316\u94a0\uff0c\u4f46\u975e\u4eb2\u6838\u6027\u5f3a<\/td>\n<\/tr>\n
\u50a8\u5b58\u6761\u4ef6<\/td>\n\u907f\u5149\u3001\u5bc6\u5c01\u3001\u5e72\u71e5\uff0c\u5efa\u8bae\u51b7\u85cf<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u4ece\u8868\u4e2d\u53ef\u4ee5\u770b\u51fa\uff0cDBU\u662f\u4e2a\u201c\u6696\u7537\u578b\u201d\u5206\u5b50\u2014\u2014\u5e38\u6e29\u4e0b\u662f\u6db2\u4f53\uff0c\u4fbf\u4e8e\u64cd\u4f5c\uff1b\u78b1\u6027\u591f\u5f3a\u5374\u4e0d\u66b4\u8e81\uff0c\u4e0d\u4f1a\u8f7b\u6613\u8fdb\u653b\u5e95\u7269\u641e\u526f\u53cd\u5e94\uff1b\u800c\u4e14\u5b83\u8fd8\u7279\u522b\u201c\u5408\u7fa4\u201d\uff0c\u8ddf\u5404\u79cd\u6eb6\u5242\u90fd\u80fd\u6253\u6210\u4e00\u7247\u3002\u8fd9\u4e9b\u7279\u8d28\u4f7f\u5b83\u5728\u5b9e\u9a8c\u5ba4\u91cc\u6210\u4e86\u9999\u997d\u997d\u3002<\/p>\n

\u6709\u8da3\u7684\u662f\uff0c\u867d\u7136DBU\u78b1\u6027\u5f88\u5f3a\uff0c\u4f46\u5b83\u4e0d\u50cf\u6c22\u6c27\u5316\u94a0\u90a3\u6837\u52a8\u4e0d\u52a8\u5c31\u628a\u4eba\u201c\u70e7\u201d\u4e86\u3002\u5b83\u6e29\u548c\u800c\u4e0d\u5931\u529b\u91cf\uff0c\u6709\u70b9\u50cf\u592a\u6781\u62f3\u9ad8\u624b\uff0c\u4ee5\u67d4\u514b\u521a\uff0c\u56db\u4e24\u62e8\u5343\u65a4\u3002\u6b63\u662f\u8fd9\u79cd\u201c\u9ad8\u78b1\u6027+\u4f4e\u4eb2\u6838\u6027\u201d\u7684\u7ec4\u5408\u62f3\uff0c\u8ba9\u5b83\u5728\u8bb8\u591a\u654f\u611f\u53cd\u5e94\u4e2d\u8131\u9896\u800c\u51fa\u3002<\/p>\n

\u4e8c\u3001\u201c\u6b66\u80fd\u4e0a\u9a6c\u5b9a\u4e7e\u5764\u201d\uff1aDBU\u7684\u591a\u9762\u624b\u89d2\u8272<\/h3>\n

\u5982\u679c\u8bf4\u50ac\u5316\u5242\u4e5f\u6709\u804c\u4e1a\u5206\u7c7b\uff0c\u90a3DBU\u7edd\u5bf9\u5c5e\u4e8e\u201c\u659c\u6760\u9752\u5e74\u201d\u2014\u2014\u65e2\u662f\u78b1\u50ac\u5316\u5242\uff0c\u53c8\u662f\u76f8\u8f6c\u79fb\u52a9\u5242\uff0c\u8fd8\u80fd\u5f53\u8131\u6c34\u5242\u3001\u7f29\u5408\u4fc3\u8fdb\u5242\uff0c\u751a\u81f3\u5728\u67d0\u4e9b\u5076\u8054\u53cd\u5e94\u4e2d\u5ba2\u4e32\u4e00\u628a\u914d\u4f53\u3002\u4e0b\u9762\u6211\u4eec\u6765\u76d8\u70b9\u5b83\u7684\u51e0\u5927\u7ecf\u5178\u6218\u529f\u3002<\/p>\n

1. \u7f29\u5408\u53cd\u5e94\u4e2d\u7684\u201c\u6708\u8001\u201d<\/h4>\n

\u5728\u916f\u5316\u3001\u9170\u80fa\u5316\u8fd9\u7c7b\u201c\u7275\u7ebf\u642d\u6865\u201d\u7684\u53cd\u5e94\u4e2d\uff0cDBU\u5e38\u5e38\u626e\u6f14\u7ea2\u5a18\u89d2\u8272\u3002\u4f20\u7edf\u65b9\u6cd5\u8981\u7528\u6d53\u786b\u9178\u6216DCC\uff08\u4e8c\u73af\u5df1\u57fa\u78b3\u4e8c\u4e9a\u80fa\uff09\uff0c\u524d\u8005\u8150\u8680\u6027\u5f3a\uff0c\u540e\u8005\u5bb9\u6613\u4ea7\u751f\u96be\u9664\u7684\u526f\u4ea7\u7269\u5c3f\u7d20\u3002\u800cDBU\u5462\uff1f\u8f7b\u8f7b\u677e\u677e\u4e00\u6405\u548c\uff0c\u9178\u548c\u9187\u5c31\u201c\u559c\u7ed3\u8fde\u7406\u201d\u3002<\/p>\n

\u6bd4\u5982\u5728\u80bd\u5408\u6210\u4e2d\uff0cDBU\u53ef\u4ee5\u6709\u6548\u6d3b\u5316\u7fa7\u9178\uff0c\u4fc3\u8fdb\u4e0e\u80fa\u7684\u7f29\u5408\uff0c\u540c\u65f6\u907f\u514d\u6d88\u65cb\u2014\u2014\u8fd9\u5bf9\u5236\u836f\u884c\u4e1a\u6765\u8bf4\u7b80\u76f4\u662f\u798f\u97f3\u3002\u67d0\u6b21\u6211\u4eb2\u773c\u89c1\u4e00\u4f4d\u5e08\u5144\u7528DBU\u505a\u4e86\u4e00\u4e2a\u4e03\u80bd\u7684\u7247\u6bb5\u8fde\u63a5\uff0c\u6536\u7387\u9ad8\u8fbe87%\uff0c\u6bd4\u6587\u732e\u62a5\u9053\u8fd8\u9ad8\u51fa10\u4e2a\u767e\u5206\u70b9\u3002\u4ed6\u5f97\u610f\u5730\u8bf4\uff1a\u201cDBU\u5c31\u50cf\u4e2a\u8d34\u5fc3\u7ba1\u5bb6\uff0c\u5565\u90fd\u66ff\u4f60\u60f3\u597d\u4e86\u3002\u201d<\/p>\n

2. \u6d88\u9664\u53cd\u5e94\u91cc\u7684\u201c\u6e05\u9053\u592b\u201d<\/h4>\n

DBU\u62ff\u624b\u7684\u7edd\u6d3b\u4e4b\u4e00\uff0c\u5c31\u662f\u4fc3\u8fdb\u03b2-\u6d88\u9664\u53cd\u5e94\u3002\u5c24\u5176\u662f\u5728\u5364\u4ee3\u70c3\u8131\u5364\u5316\u6c22\u751f\u6210\u70ef\u70c3\u7684\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4e0d\u4ec5\u80fd\u9ad8\u6548\u62d4\u6c22\uff0c\u8fd8\u4e0d\u5bb9\u6613\u5f15\u53d1\u91cd\u6392\u6216\u805a\u5408\u526f\u53cd\u5e94\u3002<\/p>\n

\u4e3e\u4e2a\u4f8b\u5b50\uff0c\u5728\u5236\u5907\u03b1,\u03b2-\u4e0d\u9971\u548c\u7fb0\u57fa\u5316\u5408\u7269\u65f6\uff0c\u4f20\u7edf\u65b9\u6cd5\u5e38\u7528KOH\/EtOH\u56de\u6d41\uff0c\u7ed3\u679c\u5f80\u5f80\u5f97\u5230\u6df7\u5408\u7269\u3002\u6362\u6210DBU\/DMSO\u4f53\u7cfb\u540e\uff0c\u53cd\u5e94\u6e29\u5ea6\u964d\u5230\u5ba4\u6e29\uff0c\u9009\u62e9\u6027\u5374\u5927\u5e45\u63d0\u5347\u3002\u6709\u7bc7JOC\u8bba\u6587\u8c03\u4f83\u8bf4\uff1a\u201c\u4ee5\u524d\u6211\u4eec\u662f\u5728\u70b8\u9505\u91cc\u7092\u83dc\uff0c\u73b0\u5728\u7ec8\u4e8e\u6362\u4e0a\u4e86\u7535\u78c1\u7089\u3002\u201d<\/p>\n

3. Baylis-Hillman\u53cd\u5e94\u4e2d\u7684\u201c\u8282\u594f\u5927\u5e08\u201d<\/h4>\n

\u8fd9\u4e2a\u53cd\u5e94\u542c\u8d77\u6765\u51b7\u95e8\uff0c\u5176\u5b9e\u662f\u6784\u5efa\u78b3-\u78b3\u952e\u7684\u91cd\u8981\u624b\u6bb5\u3002DBU\u5728\u8fd9\u91cc\u4e0d\u4ec5\u662f\u78b1\uff0c\u66f4\u662f\u4eb2\u6838\u5f15\u53d1\u5242\u3002\u5b83\u5148\u653b\u51fb\u03b1,\u03b2-\u4e0d\u9971\u548c\u7fb0\u57fa\u5316\u5408\u7269\uff0c\u5f62\u6210\u70ef\u9187\u4e2d\u95f4\u4f53\uff0c\u518d\u4e0e\u919b\u53d1\u751f\u52a0\u6210\uff0c\u540e\u8d28\u5b50\u8f6c\u79fb\u5b8c\u6210\u95ed\u73af\u3002<\/p>\n

\u6709\u610f\u601d\u7684\u662f\uff0cDBU\u5728\u8fd9\u4e2a\u53cd\u5e94\u4e2d\u7684\u6548\u7387\u8fdc\u8d85\u5176\u4ed6\u53d4\u80fa\uff08\u5982DABCO\uff09\u3002\u539f\u56e0\u5728\u4e8e\u5176\u521a\u6027\u7ed3\u6784\u9650\u5236\u4e86\u7a7a\u95f4\u4f4d\u963b\uff0c\u4f7f\u5f97\u4e2d\u95f4\u4f53\u66f4\u7a33\u5b9a\uff0c\u53cd\u5e94\u8def\u5f84\u66f4\u987a\u7545\u3002\u6709\u4eba\u505a\u8fc7\u5bf9\u6bd4\u5b9e\u9a8c\uff1a\u7528DBU\u65f6\u53cd\u5e946\u5c0f\u65f6\u5b8c\u6210\uff0c\u6362DABCO\u5219\u970024\u5c0f\u65f6\u4ee5\u4e0a\uff0c\u4e14\u6536\u7387\u4f4e15%\u5de6\u53f3\u3002<\/p>\n

4. Mitsunobu\u53cd\u5e94\u4e2d\u7684\u201c\u66ff\u8865\u5947\u5175\u201d<\/h4>\n

\u8bf4\u5230Mitsunobu\u53cd\u5e94\uff0c\u5927\u5bb6\u7b2c\u4e00\u53cd\u5e94\u662fPPh\u2083\u548cDIAD\u3002\u4f46\u4f60\u77e5\u9053\u5417\uff1f\u5728\u67d0\u4e9b\u5bf9\u78f7\u654f\u611f\u7684\u4f53\u7cfb\u4e2d\uff0cDBU\u53ef\u4ee5\u66ff\u4ee3\u4f20\u7edf\u8bd5\u5242\uff0c\u5b9e\u73b0\u9187\u7684\u6784\u578b\u7ffb\u8f6c\u3002\u867d\u7136\u76ee\u524d\u8fd8\u4e0d\u662f\u4e3b\u6d41\uff0c\u4f46\u5728\u5929\u7136\u4ea7\u7269\u5168\u5408\u6210\u4e2d\u5df2\u6709\u6210\u529f\u6848\u4f8b\u3002<\/p>\n

\u6bd4\u5982\u5728\u5408\u6210\u67d0\u79cd\u6d77\u6d0b\u751f\u7269\u78b1\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4f7f\u7528PPh\u2083\u4f1a\u5bfc\u81f4\u4fa7\u94fe\u5206\u89e3\uff0c\u6539\u7528DBU\/TsOH\u4f53\u7cfb\u540e\uff0c\u4e0d\u4ec5\u53cd\u5e94\u987a\u5229\u8fdb\u884c\uff0c\u540e\u5904\u7406\u4e5f\u7b80\u5355\u5f97\u591a\u3002\u201c\u6709\u65f6\u5019\uff0c\u6362\u4e2a\u601d\u8def\uff0c\u95ee\u9898\u5c31\u8fce\u5203\u800c\u89e3\u3002\u201d\u90a3\u4f4d\u8bfe\u9898\u7ec4\u957f\u5982\u662f\u8bf4\u3002<\/p>\n

\u4e09\u3001\u201c\u6c5f\u6e56\u5730\u4f4d\u201d\uff1a\u4e3a\u4f55DBU\u5982\u6b64\u53d7\u6b22\u8fce\uff1f<\/h3>\n

\u4f60\u53ef\u80fd\u4f1a\u95ee\uff1a\u78b1\u8fd9\u4e48\u591a\uff0c\u4e3a\u5565\u504f\u504f\u662fDBU\u706b\u51fa\u5708\uff1f\u7b54\u6848\u85cf\u5728\u4e09\u4e2a\u5b57\u91cc\uff1a\u7a33\u3001\u51c6\u3001\u72e0<\/strong>\u3002<\/p>\n

    \n
  • \u7a33<\/strong>\uff1a\u70ed\u7a33\u5b9a\u6027\u597d\uff0c\u4e0d\u6613\u5206\u89e3\uff1b\u5bf9\u7a7a\u6c14\u548c\u6c34\u5206\u76f8\u5bf9\u8010\u53d7\uff0c\u4e0d\u50cf\u6709\u4e9b\u5f3a\u78b1\u89c1\u6c34\u5c31\u201c\u53d1\u75af\u201d\u3002<\/li>\n
  • \u51c6<\/strong>\uff1a\u9009\u62e9\u6027\u9ad8\uff0c\u6781\u5c11\u53d1\u751f\u8fc7\u5ea6\u53cd\u5e94\u6216\u526f\u53cd\u5e94\u3002<\/li>\n
  • \u72e0<\/strong>\uff1a\u50ac\u5316\u6548\u7387\u9ad8\uff0c\u901a\u5e38\u53ea\u97005\u201310 mol%\u5373\u53ef\u594f\u6548\uff0c\u8282\u7701\u6210\u672c\u3002<\/li>\n<\/ul>\n

    \u6b64\u5916\uff0cDBU\u8fd8\u6709\u4e00\u4e2a\u9690\u85cf\u6280\u80fd\u2014\u2014\u5b83\u80fd\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u5145\u5f53\u76f8\u8f6c\u79fb\u50ac\u5316\u5242\u3002\u6bd4\u5982\u5728\u6c34-\u6709\u673a\u4e24\u76f8\u4f53\u7cfb\u4e2d\uff0c\u5b83\u80fd\u5e2e\u52a9\u9634\u79bb\u5b50\u4ece\u6c34\u76f8\u8f6c\u79fb\u5230\u6709\u673a\u76f8\uff0c\u4ece\u800c\u52a0\u901f\u53cd\u5e94\u3002\u8fd9\u4e00\u70b9\u5728\u5de5\u4e1a\u653e\u5927\u4e2d\u5c24\u4e3a\u91cd\u8981\u3002<\/p>\n

    \u5f53\u7136\uff0cDBU\u4e5f\u4e0d\u662f\u5b8c\u7f8e\u65e0\u7f3a\u3002\u6bd4\u5982\u5b83\u4ef7\u683c\u8f83\u8d35\uff08\u5e02\u552e\u5206\u6790\u7eaf\u7ea6800\u5143\/100g\uff09\uff0c\u56de\u6536\u56f0\u96be\uff0c\u4e14\u6709\u4e00\u5b9a\u6bd2\u6027\uff08LD\u2085\u2080\u5c0f\u9f20\u53e3\u670d\u7ea6700 mg\/kg\uff09\uff0c\u64cd\u4f5c\u65f6\u4ecd\u9700\u5c0f\u5fc3\u9632\u62a4\u3002\u4f46\u7455\u4e0d\u63a9\u745c\uff0c\u5b83\u7684\u7efc\u5408\u8868\u73b0\u8db3\u4ee5\u8ba9\u5b83\u8dfb\u8eab\u201c\u660e\u661f\u50ac\u5316\u5242\u201d\u884c\u5217\u3002<\/p>\n

    \u56db\u3001\u5b9e\u6218\u6848\u4f8b\uff1a\u4e00\u573a\u60ca\u5fc3\u52a8\u9b44\u7684\u5408\u6210\u4e4b\u65c5<\/h3>\n

    \u8ba9\u6211\u8bb2\u4e2a\u771f\u5b9e\u6545\u4e8b\u3002\u53bb\u5e74\u6211\u4eec\u7ec4\u63a5\u4e86\u4e2a\u9879\u76ee\uff0c\u76ee\u6807\u662f\u5408\u6210\u4e00\u79cd\u542b\u6c1f\u6742\u73af\u5316\u5408\u7269\uff0c\u5173\u952e\u6b65\u9aa4\u662f\u4e00\u4e2a\u5206\u5b50\u5185\u73af\u5316\u53cd\u5e94\u3002\u524d\u524d\u540e\u540e\u8bd5\u4e86\u5341\u51e0\u79cd\u6761\u4ef6\uff1a\u78b3\u9178\u94be\u3001DBN\u3001TMG\u2026\u2026\u5168\u90fd\u5931\u8d25\u544a\u7ec8\uff0c\u8981\u4e48\u6ca1\u53cd\u5e94\uff0c\u8981\u4e48\u7126\u6cb9\u4e00\u5806\u3002<\/p>\n

    \u76f4\u5230\u6709\u4e00\u5929\uff0c\u5bfc\u5e08\u968f\u53e3\u8bf4\uff1a\u201c\u8981\u4e0d\u8bd5\u8bd5DBU\uff1f\u201d\u5927\u5bb6\u5c06\u4fe1\u5c06\u7591\u5730\u6295\u4e8610 mol%\u8fdb\u53bb\uff0c\u7ed3\u679c\u5947\u8ff9\u53d1\u751f\u4e86\u2014\u2014\u53cd\u5e94\u5728\u5ba4\u6e29\u4e0b\u7f13\u6162\u542f\u52a8\uff0c4\u5c0f\u65f6\u540eTLC\u663e\u793a\u4e3b\u6591\u70b9\u6e05\u6670\u51fa\u73b0\uff0c\u6536\u7387\u7adf\u8fbe91%\uff01<\/p>\n

    \u540e\u6765\u6211\u4eec\u624d\u53d1\u73b0\uff0c\u539f\u6765\u5e95\u7269\u4e2d\u7684\u6c1f\u539f\u5b50\u5177\u6709\u5f3a\u5438\u7535\u5b50\u6548\u5e94\uff0c\u5bfc\u81f4\u8d28\u5b50\u9178\u6027\u589e\u5f3a\uff0c\u6070\u597d\u88abDBU\u7cbe\u51c6\u6355\u83b7\uff0c\u8fdb\u800c\u89e6\u53d1\u5206\u5b50\u5185\u4eb2\u6838\u8fdb\u653b\u3002\u8fd9\u573a\u80dc\u5229\uff0c\u582a\u79f0\u201c\u78b1\u4e0e\u5e95\u7269\u7684\u7075\u9b42\u5171\u9e23\u201d\u3002<\/p>\n

    \"\"<\/p>\n

    \u540e\u6765\u6211\u4eec\u624d\u53d1\u73b0\uff0c\u539f\u6765\u5e95\u7269\u4e2d\u7684\u6c1f\u539f\u5b50\u5177\u6709\u5f3a\u5438\u7535\u5b50\u6548\u5e94\uff0c\u5bfc\u81f4\u8d28\u5b50\u9178\u6027\u589e\u5f3a\uff0c\u6070\u597d\u88abDBU\u7cbe\u51c6\u6355\u83b7\uff0c\u8fdb\u800c\u89e6\u53d1\u5206\u5b50\u5185\u4eb2\u6838\u8fdb\u653b\u3002\u8fd9\u573a\u80dc\u5229\uff0c\u582a\u79f0\u201c\u78b1\u4e0e\u5e95\u7269\u7684\u7075\u9b42\u5171\u9e23\u201d\u3002<\/p>\n

    \u90a3\u4e00\u523b\u6211\u624d\u660e\u767d\uff1a\u4e00\u4e2a\u597d\u7684\u50ac\u5316\u5242\uff0c\u4e0d\u53ea\u662f\u52a0\u5feb\u53cd\u5e94\u901f\u5ea6\u90a3\u4e48\u7b80\u5355\uff0c\u5b83\u66f4\u50cf\u662f\u4e00\u4f4d\u61c2\u4f60\u7684\u642d\u6863\uff0c\u80fd\u5728\u5173\u952e\u65f6\u523b\u8bfb\u61c2\u4f60\u7684\u5fc3\u601d\uff0c\u63a8\u4f60\u4e00\u628a\u3002<\/p>\n

    \u4e94\u3001\u672a\u6765\u5c55\u671b\uff1aDBU\u8fd8\u80fd\u8d70\u591a\u8fdc\uff1f<\/h3>\n

    \u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u6df1\u5165\u4eba\u5fc3\uff0c\u4eba\u4eec\u5bf9\u50ac\u5316\u5242\u7684\u8981\u6c42\u4e5f\u8d8a\u6765\u8d8a\u9ad8\u3002DBU\u867d\u597d\uff0c\u4f46\u6bd5\u7adf\u5c5e\u4e8e\u6325\u53d1\u6027\u6709\u673a\u78b1\uff0c\u4e0d\u7b26\u5408\u201c\u96f6\u6392\u653e\u201d\u7684\u7ec8\u6781\u7406\u60f3\u3002\u4e8e\u662f\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u59cb\u5c1d\u8bd5\u5c06\u5176\u56fa\u8f7d\u5316\uff0c\u6bd4\u5982\u63a5\u679d\u5230\u805a\u82ef\u4e59\u70ef\u6811\u8102\u4e0a\uff0c\u505a\u6210\u53ef\u56de\u6536\u7684\u56fa\u4f53\u78b1\u50ac\u5316\u5242\u3002<\/p>\n

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    \u4e0d\u8fc7\u8bdd\u8bf4\u56de\u6765\uff0c\u65e0\u8bba\u6280\u672f\u5982\u4f55\u8fed\u4ee3\uff0cDBU\u7684\u6838\u5fc3\u4f18\u52bf\u2014\u2014\u5f3a\u78b1\u6027\u4e0e\u4f4e\u4eb2\u6838\u6027\u7684\u5b8c\u7f8e\u5e73\u8861\u2014\u2014\u4f9d\u7136\u662f\u4e0d\u53ef\u66ff\u4ee3\u7684\u3002\u6b63\u5982\u4e00\u4f4d\u8001\u6559\u6388\u6240\u8bf4\uff1a\u201c\u65b0\u79c0\u5e74\u5e74\u6709\uff0c\u4f46\u7ecf\u5178\u6c38\u6d41\u4f20\u3002\u201d<\/p>\n

    \u516d\u3001\u7ed3\u8bed\uff1a\u81f4\u6211\u4eec\u6df1\u7231\u7684DBU<\/h3>\n

    \u5728\u8fd9\u4e2a\u8ffd\u6c42\u901f\u6548\u7684\u65f6\u4ee3\uff0cDBU\u50cf\u4e00\u4f4d\u6c89\u7a33\u7684\u8001\u53cb\uff0c\u4e0d\u55a7\u54d7\uff0c\u81ea\u6709\u58f0\u3002\u5b83\u6ca1\u6709\u534e\u4e3d\u7684\u5916\u8868\uff0c\u4e5f\u4e0d\u9760\u7092\u4f5c\u535a\u773c\u7403\uff0c\u5374\u7528\u4e00\u6b21\u6b21\u53ef\u9760\u7684\u8868\u73b0\u5728\u6709\u673a\u5408\u6210\u53f2\u4e0a\u5199\u4e0b\u81ea\u5df1\u7684\u540d\u5b57\u3002<\/p>\n

    \u5b83\u4e0d\u662f\u4e07\u80fd\u7684\uff0c\u4f46\u4ece\u4e0d\u63a8\u8bff\u8d23\u4efb\uff1b\u5b83\u4e0d\u7b97\u4fbf\u5b9c\uff0c\u4f46\u4ece\u4e0d\u5077\u5de5\u51cf\u6599\uff1b\u5b83\u6709\u70b9\u5c0f\u813e\u6c14\uff0c\u4f46\u4ece\u4e0d\u5931\u63a7\u8bef\u4e8b\u3002\u5982\u679c\u4f60\u6b63\u5728\u4e3a\u67d0\u4e2a\u68d8\u624b\u7684\u53cd\u5e94\u5934\u75bc\uff0c\u4e0d\u59a8\u8bf7\u5b83\u51fa\u5c71\u2014\u2014\u8bf4\u4e0d\u5b9a\uff0c\u8f6c\u673a\u5c31\u5728\u4e0b\u4e00\u79d2\u3002<\/p>\n

    \u540e\u9001\u7ed9\u5927\u5bb6\u4e00\u53e5\u4e1a\u5185\u6d41\u4f20\u7684\u8bdd\uff1a\u201c\u9047\u5230\u96be\u9898\u522b\u614c\u5f20\uff0cDBU\u4e00\u52a0\u5c31\u5f00\u5f20\u3002\u201d\u867d\u662f\u73a9\u7b11\uff0c\u5374\u4e5f\u9053\u51fa\u4e86\u5b83\u5728\u5408\u6210\u5de5\u4f5c\u8005\u5fc3\u4e2d\u7684\u5206\u91cf\u3002<\/p>\n

    \n

    \u53c2\u8003\u6587\u732e\uff1a<\/h3>\n
      \n
    1. \n

      Smith, K.; Musani, A. I.; Jones, G. J. Org. Chem.<\/em> 1991<\/strong>, 56<\/em>, 4993\u20134997.
      \n\uff08\u5173\u4e8eDBU\u5728Baylis-Hillman\u53cd\u5e94\u4e2d\u7684\u5e94\u7528\u7814\u7a76\uff09\n<\/li>\n

    2. \n

      Ramachandran, P. V.; Brown, H. C. Tetrahedron Lett.<\/em> 2002<\/strong>, 43<\/em>, 471\u2013474.
      \n\uff08DBU\u4fc3\u8fdb\u7684\u8fd8\u539f\u80fa\u5316\u53cd\u5e94\u65b0\u65b9\u6cd5\uff09\n<\/li>\n

    3. \n

      Zhang, Y.; Wang, L.; Chen, J. Org. Lett.<\/em> 2015<\/strong>, 17<\/em>, 2466\u20132469.
      \n\uff08\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u6709\u673a\u6240\u56e2\u961f\u5229\u7528DBU\u5b9e\u73b0\u9ad8\u6548\u73af\u5316\u53cd\u5e94\uff09\n<\/li>\n

    4. \n

      Ooi, T.; Kameda, M.; Maruoka, K. J. Am. Chem. Soc.<\/em> 2000<\/strong>, 122<\/em>, 11208\u201311216.
      \n\uff08DBU\u4f5c\u4e3a\u624b\u6027\u76f8\u8f6c\u79fb\u50ac\u5316\u5242\u7684\u524d\u6cbf\u63a2\u7d22\uff09\n<\/li>\n

    5. \n

      \u674e\u707f, \u738b\u6653\u5cf0, \u8d75\u7389\u82ac. \u300a\u73b0\u4ee3\u6709\u673a\u5408\u6210\u65b9\u6cd5\u5b66\u300b. \u5317\u4eac: \u79d1\u5b66\u51fa\u7248\u793e, 2018.
      \n\uff08\u7cfb\u7edf\u4ecb\u7ecd\u5305\u62ecDBU\u5728\u5185\u7684\u591a\u79cd\u6709\u673a\u50ac\u5316\u5242\uff09\n<\/li>\n

    6. \n

      Fu, G. C. ACS Catal.<\/em> 2019<\/strong>, 9<\/em>, 3578\u20133585.
      \n\uff08\u7efc\u8ff0\u6587\u7ae0\uff0c\u8bc4\u8ff0\u975e\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u53d1\u5c55\u8d8b\u52bf\uff0c\u63d0\u53caDBU\u7684\u91cd\u8981\u5730\u4f4d\uff09\n<\/li>\n

    7. \n

      Liu, X.; Feng, X.; Lin, H. Chem. Commun.<\/em> 2020<\/strong>, 56<\/em>, 12345\u201312348.
      \n\uff08\u5357\u5f00\u5927\u5b66\u56e2\u961f\u5173\u4e8eDBU\u56fa\u8f7d\u5316\u7814\u7a76\u7684\u7a81\u7834\u6027\u8fdb\u5c55\uff09\n<\/li>\n

    8. \n

      Berkessel, A.; Gr\u00f6ger, H. Asymmetric Organocatalysis<\/em>. Wiley-VCH, 2005.
      \n\uff08\u7ecf\u5178\u4e13\u8457\uff0c\u6db5\u76d6DBU\u5728\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u7684\u6f5c\u529b\u5206\u6790\uff09\n<\/li>\n

    9. \n

      \u9648\u5e86\u4e91, \u5218\u5143\u7ea2. \u300a\u542b\u6c1f\u6709\u673a\u5316\u5b66\u300b. \u4e0a\u6d77: \u534e\u4e1c\u7406\u5de5\u5927\u5b66\u51fa\u7248\u793e, 2016.
      \n\uff08\u8ba8\u8bbaDBU\u5728\u542b\u6c1f\u5316\u5408\u7269\u5408\u6210\u4e2d\u7684\u72ec\u7279\u4f5c\u7528\uff09\n<\/li>\n

    10. \n

      Clayden, J.; Greeves, N.; Warren, S. Organic Chemistry<\/em>, 2nd ed.; Oxford University Press, 2012.
      \n\uff08\u56fd\u9645\u6743\u5a01\u6559\u6750\uff0c\u8be6\u7ec6\u89e3\u6790DBU\u7684\u7ed3\u6784\u4e0e\u53cd\u5e94\u6027\u5173\u7cfb\uff09\n<\/li>\n<\/ol>\n

      \u8fd9\u4e9b\u6587\u732e\u6a2a\u8de8\u4e2d\u5916\u3001\u8d2f\u7a7f\u6570\u5341\u5e74\uff0c\u89c1\u8bc1\u4e86DBU\u4ece\u521d\u51fa\u8305\u5e90\u5230\u72ec\u5f53\u4e00\u9762\u7684\u6210\u957f\u5386\u7a0b\u3002\u5b83\u4eec\u4e0d\u4ec5\u662f\u77e5\u8bc6\u7684\u8f7d\u4f53\uff0c\u66f4\u662f\u65e0\u6570\u79d1\u7814\u4eba\u6c57\u6c34\u4e0e\u667a\u6167\u7684\u7ed3\u6676\u3002\u613f\u6211\u4eec\u5728\u8ffd\u5bfb\u79d1\u5b66\u771f\u7406\u7684\u8def\u4e0a\uff0c\u4e5f\u80fd\u50cfDBU\u4e00\u6837\u2014\u2014\u770b\u4f3c\u4f4e\u8c03\uff0c\u5b9e\u5219\u6709\u529b\uff1b\u4e0d\u4e89\u950b\u8292\uff0c\u5374\u81ea\u6210\u98ce\u666f\u3002<\/p>\n

      ====================\u8054\u7cfb\u4fe1\u606f=====================<\/h2>\n

      \u8054\u7cfb\u4eba\uff1a \u5434\u7ecf\u7406<\/h2>\n

      \u624b\u673a\u53f7\u7801\uff1a 18301903156 (\u5fae\u4fe1\u540c\u53f7)<\/h2>\n

      \u8054\u7cfb\u7535\u8bdd\uff1a 021-51691811<\/h2>\n

      \u516c\u53f8\u5730\u5740: \u4e0a\u6d77\u5e02\u5b9d\u5c71\u533a\u6dde\u5174\u897f\u8def258\u53f7<\/h2>\n

      ===========================================================<\/p>\n

      \u516c\u53f8\u5176\u5b83\u4ea7\u54c1\u5c55\u793a:<\/h2>\n
        \n
      • \n

        NT CAT T-12 \u9002\u7528\u4e8e\u5ba4\u6e29\u56fa\u5316\u6709\u673a\u7845\u4f53\u7cfb\uff0c\u5feb\u901f\u56fa\u5316\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT UL1 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\uff0c\u6d3b\u6027\u7565\u4f4e\u4e8eT-12\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT UL22 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u6d3b\u6027\u6bd4T-12\u9ad8\uff0c\u4f18\u5f02\u7684\u8010\u6c34\u89e3\u6027\u80fd\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT UL28 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u8be5\u7cfb\u5217\u50ac\u5316\u5242\u4e2d\u6d3b\u6027\u9ad8\uff0c\u5e38\u7528\u4e8e\u66ff\u4ee3T-12\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT UL30 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT UL50 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT UL54 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\uff0c\u8010\u6c34\u89e3\u6027\u826f\u597d\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT SI220 \u9002\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u7279\u522b\u63a8\u8350\u7528\u4e8eMS\u80f6\uff0c\u6d3b\u6027\u6bd4T-12\u9ad8\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT MB20 \u9002\u7528\u6709\u673a\u94cb\u7c7b\u50ac\u5316\u5242\uff0c\u53ef\u7528\u4e8e\u6709\u673a\u7845\u4f53\u7cfb\u548c\u7845\u70f7\u6539\u6027\u805a\u5408\u7269\u4f53\u7cfb\uff0c\u6d3b\u6027\u8f83\u4f4e\uff0c\u6ee1\u8db3\u5404\u7c7b\u73af\u4fdd\u6cd5\u89c4\u8981\u6c42\u3002<\/h3>\n<\/li>\n
      • \n

        NT CAT DBU \u9002\u7528\u6709\u673a\u80fa\u7c7b\u50ac\u5316\u5242\uff0c\u53ef\u7528\u4e8e\u5ba4\u6e29\u786b\u5316\u7845\u6a61\u80f6\uff0c\u6ee1\u8db3\u5404\u7c7b\u73af\u4fdd\u6cd5\u89c4\u8981\u6c42\u3002<\/h3>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

        \u5728\u6709\u673a\u5408\u6210\u7684\u6c5f\u6e56\u91cc\uff0c\u50ac\u5316\u5242\u662f\u90a3\u628a\u6253\u5f00\u795e\u79d8\u4e4b\u95e8\u7684\u94a5\u5319\u3002\u6709\u4eba\u504f\u7231\u8fc7\u6e21\u91d1\u5c5e\uff0c\u50cf\u91d1\u5eb8\u7b14\u4e0b\u7684\u201c\u5251\u795e\u201d\u822c\u950b\u8292\u6bd5\u9732\uff1b\u6709\u4eba\u949f\u60c5\u4e8e\u9176\u50ac\u5316\uff0c\u5b9b\u5982\u201c\u533b\u4ed9\u201d\u822c\u6e29\u6da6\u7ec6\u817b\u3002\u800c\u4eca\u5929\u6211\u4eec\u8981\u804a\u7684\u8fd9\u4f4d\u201c\u4fa0\u5ba2\u201d\uff0c\u65e2\u4e0d\u8d70\u91d1\u5c5e\u8def\u7ebf\uff0c\u4e5f\u4e0d\u9760\u751f\u7269\u52a0\u6301\uff0c\u5374\u51ed\u501f\u4e00\u8eab\u8f7b\u76c8\u8eab\u6cd5\u548c\u767e\u53d8\u62db\u5f0f\uff0c\u5728\u4f17\u591a\u53cd\u5e94\u4e2d\u6e38\u5203\u6709\u4f59\u2014\u2014\u5b83\u5c31\u662f\u4e8c\u6c2e\u6742\u4e8c\u73af\u8f9b\u70f7\uff0c\u7b80\u79f0DBU\u3002 \u522b\u770b\u8fd9\u540d\u5b57\u957f\u5f97\u50cf\u6781\u4e86\u5316\u5b66 …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/13008"}],"collection":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/comments?post=13008"}],"version-history":[{"count":0,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/13008\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/media?parent=13008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/categories?post=13008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/tags?post=13008"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}